The presence of calcium and its release from the material during the healing process can mediate the expression of osteopontin, which binds to bone hydroxyapatite, participates in its formation, and has an integrin-binding domain, which promotes cell proliferation on the implant surface. The presence of calcium and phosphorus ions in the composition of these materials imparts osteoconductive properties to the implant. This led to the development of matrices and scaffolds with specified physicochemical properties based on biocompatible calcium phosphates-hydroxyapatite and tricalcium phosphate. A large number of works are devoted to bioresorbable materials for maximum imitation of the structure and properties of native bone tissue. The bones regeneration processes studies, rather than mechanical replacement of bone tissue, lead to the creation of various combinations of materials based on calcium phosphate ceramics and its composites for bone augmentation procedures. The results of the study indicate the effectiveness of using strontium in OCP for improving biocompatibility of OCP based composite materials intended for bone repair. The effect of strontium substitution range on changes in the crystal lattice of materials, the microstructural features, surface morphology and biological properties in vitro has been established. The processes of phase formation of low-temperature OCP with theoretical substitution of strontium for calcium up to 50 at.% in conditions close to physiological, i.e., temperature 35–37 ☌ and normal pressure, were described. Strontium was inserted into the OCP structure by ionic substitution in solutions. Strontium is used to improve bioactive properties of the material.
In this work, the synthesis of low-temperature calcium phosphate compounds and substituted forms of those at physiological temperatures is shown. OCP has higher biocompatibility and osseointegration rate compared to other calcium phosphates. Drop image files to iVinci window to import images, Drop SVG files to iVinci window to open it.Octacalcium phosphate (OCP, Ca 8H 2(PO 4) 6♵H 2O) is known to be a possible precursor of biological hydroxyapatite formation of organic bone tissue. Use arrow keys to move the selected objects. To change gradient color, select any color item in gradient first, then select color in the color panel. While editing gradient, both the position of gradient line and position of gradient color is movable. To modify gradient, select object with object selector, click gradient type for stroke or fill(even if it is already selected), or right button click on the object and use corresponding menu items. To make one cuver be straight line, simply remove the tangent point. To make the path smooth or sharp at any control point, select point with point selector, and then right button click to see options. To add new control point on the path, select object with point selector, right button click on the position you want to place the new point, select "Add Point" menu item. Press and hold "shift" or "command" key to select multiple layers. Press and hold "shift" or "command" key to select multiple points with point selector. Press and hold "shift" or "command" key to select multiple objects with object selector. If the curve is not smooth at the point, you do not have to press "alt" key. Press and hold "alt" key to move the tangent point individually.
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